Spontaneous Hypoglycemia in Childhood Is Accompanied by Paradoxically Low Serum Growth Hormone and Appropriate Cortisol Counterregulatory Hormonal Responses
نویسندگان
چکیده
منابع مشابه
Serum glucagon counterregulatory hormonal response to hypoglycemia is blunted in congenital hyperinsulinism.
The mechanisms involved in the release of glucagon in response to hypoglycemia are unclear. Proposed mechanisms include the activation of the autonomic nervous system via glucose-sensing neurons in the central nervous system, via the regulation of glucagon secretion by intra-islet insulin and zinc concentrations, or via direct ionic control, all mechanisms that involve high-affinity sulfonylure...
متن کاملDiazoxide improves hormonal counterregulatory responses to acute hypoglycemia in long- standing Type 1 Diabetes Short Title; Diazoxide improves hypoglycemia responses
Individuals with long-standing type 1 diabetes (T1D) are at increased risk of severe hypoglycemia secondary to impairments in normal glucose counterregulatory responses (CRR). Strategies to prevent hypoglycemia are often ineffective highlighting the need for novel therapies. ATP-sensitive potassium (KATP) channels within the hypothalamus are thought to be integral to hypoglycemia detection and ...
متن کاملDiazoxide improves hormonal counterregulatory responses to acute hypoglycemia in long-standing type 1 diabetes.
Individuals with long-standing type 1 diabetes (T1D) are at increased risk of severe hypoglycemia secondary to impairments in normal glucose counterregulatory responses (CRRs). Strategies to prevent hypoglycemia are often ineffective, highlighting the need for novel therapies. ATP-sensitive potassium (KATP) channels within the hypothalamus are thought to be integral to hypoglycemia detection an...
متن کاملCortisol acts through central mechanisms to blunt counterregulatory responses to hypoglycemia in conscious rats.
Physiological levels of cortisol have been found to blunt neuroendocrine and metabolic responses to subsequent hypoglycemia in humans. The aim of this study was to determine whether cortisol acts directly on the brain to elicit this effect. A total of 41 conscious unrestrained Sprague-Dawley rats were studied during 2-day experiments. Day 1 consisted of two episodes of clamped 2-h hyperinsuline...
متن کاملCounterregulatory hormone and symptom responses to insulin-induced hypoglycemia in the postprandial state in humans.
Plasma counterregulatory hormones and symptoms were measured during hypoglycemia in the postprandial and in the fasting state in humans to establish differences in physiological responses. We studied 8 nondiabetic subjects and 10 subjects with type 1 diabetes on two different occasions during clamped insulin-induced hypoglycemia (2.4 mmol/l) in the sitting position. On one occasion, subjects at...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2003
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2003-030137